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The subject is presented consistently in a unified geometric formalism, relying on the calculus of exterior forms and the mathematics needed to develop the theory is explained in appropriate chapters.

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This paper examines how geometric regularities in abstract ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...