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MRG15可变剪接调控CDK1转录活性在细胞衰老与心肌再生中的机制研究
随着表观遗传学的兴起,科学家们逐渐认识到染色质结构的动态变化在衰老进程中扮演关键角色。其中,染色质重塑蛋白MRG15(MORF-related gene on chromosome 15)虽被多次报道与衰老相关,但其具体机制仍存在两大谜团:为何敲低和过表达MRG15均会引发矛盾的表型?
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