研究发现AMPK信号通过磷酸化Beclin1的苏氨酸388位点从而调控细胞自噬，进一步揭示了自噬的发生发展的分子机制，为解析细胞自噬奠定了一定的理论基础。 自噬领域国际学术期刊Autophagy 在线发表了中国科学院上海生命科学研究 ...

Autophagy ：揭示巨噬 ... 利用AMPK激动剂AICAR能够有效回复VEGFR3突变体对糖代谢重编程和炎症小体活化的作用。 ...

Autophagy：揭示巨噬细胞调控糖代谢和清除细菌的机制. 巨噬细胞; 来源：分子细胞卓越中心 2021-10-19 18:41 巨噬细胞通过模式识别受体等机制，识别细菌 ...

This review discusses the cellular process of autophagy ... Viollet, B, Guan, KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011;13:132-141. Crossref ...

Once AMPK is activated, it activates autophagy and then the induced autophagy increases gene expression of appetite-stimulating neuropeptides and decreases that of appetite -inhibiting neuropeptides.

AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains metabolic homeostasis by reprogramming growth, metabolism, and autophagy in the face of ...

AMPK positively regulates catabolic pathways such as fatty acid oxidation and autophagy when the concentration of intracellular ATP is low, while it negatively affects anabolic pathways such as ...