Telitacicept is a dual-targeting agent that attaches to and blocks the effects of 2 key signaling proteins, B-lymphocyte ...

Idiopathic autonomic neuropathy is a severe, subacute disorder with a presumed autoimmune basis. It is indistinguishable from the subacute autonomic neuropathy that may accompany lung cancer or ...

Figure 1: Antibodies from AChR-Ab–seronegative MG patients bind to MuSK. Figure 3: MuSK IgG antibodies induce AChR clusters but inhibit agrin-induced clustering. COS7 cells were plated onto ...

The new report suggests patients with acetylcholine receptor (AChR) antibody titers above 8.11 nmol/L were at higher risk of conversion. Antibody titers in patients with acetylcholine receptor ...

Most people with generalized myasthenia gravis (gMG) have antibodies in their body that attack acetylcholine receptors at the neuromuscular junction, the place where nerve cells and muscle cells ...

People who suffer from the autoimmune disease myasthenia gravis experience muscle weakness that can affect any of the muscles we use to blink, smile or even move our body around. Researchers have ...

In healthy people, binding of the molecule acetylcholine (ACh) to its receptor (AChR) on skeletal muscle cells triggers muscle contraction underlying regular daily activities. In the autoimmune ...

Autoimmune generalized myasthenia gravis is a disease that manifests with fluctuating muscle weakness. Inebilizumab is a monoclonal antibody that depletes CD19+ B cells, which are central to ...

The phase 3 MINT trial included more than 200 adults with anti–acetylcholine receptor antibody–positive (AChR+) or muscle-specific kinase antibody–positive (MuSK+) generalized MG.

You’ll receive it weekly for 4 weeks, followed by every 2 weeks, and is approved for people who have tested positive for anti-acetylcholine receptor antibodies. Taking eculizumab may increase ...

In the Phase 3 MG study, batoclimab met its primary endpoint of mean change from baseline in Myasthenia Gravis Activities of Daily Living (MG-ADL) score in acetylcholine receptor antibody positive ...

In MG, immune proteins called antibodies mistakenly block or destroy receptors for a neurotransmitter called acetylcholine. Among other functions, acetylcholine initiates the transmission of ...