Background: Biomarkers of stroke are an evolving field of clinical research. A serum marker which can differentiate between haemorrhagic and ischaemic stroke in the very early phase would help to ...

Adeno-associated viruses encoding Cre-GFP or GFP under the liver-specific TBG promoter (AAV8-TBG-Cre-GFP, and AAV8-GFP used as a negative control) were prepared by the Vector Core of the Pennsylvania ...

本研究针对长期糖皮质激素治疗引发的代谢副作用，揭示了S1PR2（鞘氨醇-1-磷酸受体2）通过激活Srebp1c（固醇调节元件结合蛋白1c）和ChREBP（碳水化合物反应元件结合蛋白）信号通路，促进肝脏脂质合成和糖酵解的关键机制。研究人员通过AAV8介导的肝脏特异性基因敲降、RNA测序和染色质免疫沉淀等 ...

(美国商业资讯)-- 体外诊断领域的领先创新企业Fujirebio今日宣布与位于美国加州帕洛阿尔托的斯坦福大学医学院达成合作，共同推进传染病检测领域 ...

Methods Details of the study design have been previously described. Briefly, nine patients were treated in three escalating dose groups with subretinal AAV8.CNGA3 gene therapy between November 2015 ...

GFAP and UCH-L1 are released into the systemic circulation following TBI and have been found to be elevated in the serum during the acute phase of TBI. 5,7,10 Studies have shown that serum GFAP ...

TET2 is recruited by HNF4α, contributing to the demethylation of the FBP1 promoter and activating its expression in response to glucagon stimulation. Moreover, ... AAV8 and AAV8-shTet2 were diluted ...

G3P binds directly to the transcription factor ChREBP to activate it, and acetyl-CoA is used to modify histones at the Fgf21 gene promoter, increasing its accessibility to ChREBP. This dual mechanism ...

aav8治疗窗口期 P1期单次注射AAV8-TBG-Sox4-shRNA可使血清胆红素水平维持正常达6个月，胆管密度恢复至野生型85%。 值得注意的是，P15期干预仍能促使5-8%的转导细胞整合入胆管结构，并改善已形成的肝坏死灶。

Bardet-Biedl syndrome (BBS) is a group of rare autosomal recessive ciliopathies characterized by dysfunction of primary cilia, which affects multiple organ systems and leads to early-onset obesity, ...