本研究针对Alagille综合征(ALGS)患者胆汁管缺乏导致的严重胆汁淤积表型，通过AAV8载体介导的Sox4基因沉默技术，在Jag1杂合缺失 ...

Bardet-Biedl syndrome (BBS) is a group of rare autosomal recessive ciliopathies characterized by dysfunction of primary cilia, which affects multiple organ systems and leads to early-onset obesity, ...

研究人员通过AAV8介导的肝脏特异性基因敲降、RNA测序和染色质免疫沉淀等技术，证实抑制S1PR2可显著缓解地塞米松诱导的肝脏甘油三酯积累和高甘油三酯血症，为开发靶向S1PR2的糖皮质激素联合疗法提供了理论依据。 糖皮质激素是临床常用的抗炎药物，但长期 ...

Understanding the longitudinal relationship between AD-related biomarkers, such as amyloid β (Aβ), phosphorylated tau (p-tau), glial fibrillary acidic protein (GFAP), total tau (t-tau), and ...

Plasma glial fibrillary acidic protein (GFAP), neurofilament light (NfL), p-tau217/Aβ42 ratio, and p-tau217 increased with age, whereas plasma Aβ42/40 ratio decreased. Females had higher plasma ...

东京和加州桑尼维尔--(BUSINESS WIRE)--(美国商业资讯)-- 体外诊断领域的领先创新企业Fujirebio今日宣布与位于美国加州帕洛阿尔托的斯坦福大学医学院 ...