Activated AKT regulates the TSC1-TSC2 complex, which controls Rheb GTPase, thereby activating mTORC1. mTORC1 promotes protein synthesis (via 4E-BP1 and S6K), lipid biogenesis (via SREBP1 and PPARγ), ...

免疫系统中的巨噬细胞以其吞噬和消化外来入侵者——例如细菌和病原体——的能力著称。作为身体的“清道夫”，巨噬细胞在感染发生时负责吞噬细菌，并通过一系列复杂的细胞内过程将其降解。然而，尽管我们对巨噬细胞吞噬功能的防御角色有所了解，但对被吞噬细菌的最终命运以及这些过程对巨噬细胞代谢的影响仍缺乏全面认识。近年来，免疫代谢学迅速发展，这一领域揭示了免疫细胞如何通过代谢重编程来适应和响应病原体的存在。不同于从 ...

If you couldn’t afford the older Cinepeer Crane 4 then the cheaper 4E is well worth a look. The Cinepeer Crane 4E may lack the Crane 4’s LED fill light (which is arguably a non-essential feature ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...

为探究急性 ST 段抬高型心肌梗死（STEMI）患者入院血糖、HbA1c 与炎症蛋白的关联，德国奥格斯堡大学研究人员开展相关研究。结果发现入院血糖与多种炎症标志物有关。该研究为开发诊断或预后临床标志物提供方向，值得一读。 在医学领域，急性 ST 段抬高型 ...

Department of Nuclear Medicine, Xinqiao Hospital, Army Medical University, Chongqing 400037, China School of Medical Imaging, North Sichuan Medical College, NanChong 637100, China Department of ...

Huawei nova 4e is released in March 2019. The smartphone is powered by Huawei HiSilicon Kirin 710, 64-bit Processor. The smartphone is packed with 4 GB RAM and the internal storage is 128 GB.

Connecting decision makers to a dynamic network of information, people and ideas, Bloomberg quickly and accurately delivers business and financial information, news and insight around the world ...

为解决肌酸转运蛋白缺乏症（CTD）在骨骼肌方面机制不明的问题，意大利佛罗伦萨大学 Irene Pertici 等人研究 CrT 敲除小鼠骨骼肌。结果发现其肌肉性能下降、线粒体 Ca2?稳态失衡及萎缩。该研究为 CTD 治疗提供关键依据，值得科研人员一读。 意大利佛罗伦萨大学 ...

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