Forty-seven patients were randomly assigned in a 1:1 ratio to the standard dose of alteplase (0.9 mg/kg, the first 10% administered as an initial bolus and the remainder over a 1-hour period, with a ...

点击上方“Vaccine前研”，关注最新疫苗动态黏膜接种疫苗是诱导针对呼吸道病原体的保护性免疫反应的关键策略。虽然黏膜递送加强疫苗即使在没有佐剂的情况下也能引发强大的局部免疫，但潜在的机制一直不明确。5月13日，耶鲁大学Akiko ...

包括鼻内接种在内的黏膜疫苗可在黏膜屏障（抵御呼吸道病原体的第一道防线）处提供更强保护。鼻内疫苗能在这些关键解剖部位诱导或增强局部IgG抗体免疫应答，同时可能激发抗原特异性IgA应答。IgA是黏膜主要抗体类别，针对相同抗原时较循环IgG抗体具有更高亲和 ...

Humans are constantly exposed to numerous viruses but the consequences of infection are different in different individuals. The outcome of host–viral interactions depend on the dose and route of ...

特别是淋巴结记忆B 细胞被确定为黏膜 IgA 反应的主要来源。使用 S1PR1激动剂 FTY720 抑制淋巴细胞从次级淋巴组织流出，导致肺部RBD 特异性 IgA+ ASC 和 ...

† Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, U.K. ‡ Target Discovery Institute, University of Oxford, ...