See related article at Key points Targeted therapy and immunotherapies are now treatment mainstays for an increasing number of cancers, often markedly improving patient survival and quality of life.

See related article at In a related analysis, Abdel-Rahman and colleagues[1][2] discuss how the marked improvement in quantity and quality of life experienced by some people with cancer who receive ...

An 81-year-old man presented to the emergency department after 2 episodes of uncontrollable shaking, each lasting several minutes, accompanied by a sensation of extreme cold. He and his partner stated ...

A 32-year-old woman presented to our emergency department 2 days after the onset of bilateral hand swelling. Two weeks earlier, her 8-year-old son had had an erythematous rash on both cheeks. A week ...

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Background In an evolving landscape of practices and policies, reviewing and incorporating the latest scientific evidence is necessary to ensure optimal clinical management for people with opioid use ...

Endometriosis is a common disorder that can cause pelvic pain and infertility, may involve multiple organ systems and can adversely affect quality of life. The cause of endometriosis is not fully ...

First-person consent for organ donation after medical assistance in dying (MAiD) or withdrawal of life-sustaining measures (WLSM) should be an option in jurisdictions that allow MAiD or WLSM and ...

Research questions The evidence synthesis team reviewed the 2010 Canadian Guideline for Safe and Effective use of Opioids for Chronic Non-Cancer Pain,13 as well as six other recently published ...

Postural orthostatic tachycardia syndrome (POTS) is a chronic multisystem disorder; the cardinal feature is orthostatic tachycardia. Patients with POTS have symptoms of orthostatic intolerance that ...

The incidence of chlamydia and gonorrhea, 2 common sexually transmitted infections, is increasing. Annual asymptomatic screening for chlamydia and gonorrhea should be performed in all sexually active ...

Velina Tzankova, Werner J. Becker and Tommy L.H. Chan Migraine is a leading cause of disability across all age groups. Routine imaging is not recommended in patients with migraine who have no red ...