MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular diseases ...

Lysosomal storage diseases comprise >40 disorders caused by deficient enzymatic activity of lysosomal enzymes that lead to accumulation of substrates in several organs. This review addresses those ...

Exercise testing with echocardiography or myocardial perfusion imaging is widely used to risk‐stratify patients with suspected coronary artery disease. However, reports of diagnostic performance ...

The molecular mechanisms that guide heart valve formation are not well understood. However, elucidation of the genetic basis of congenital heart disease is one of the prerequisites for the development ...

Obesity has been shown to promote renin–angiotensin system activity and inflammation in the brain and to be accompanied by increased sympathetic activity and blood pressure. Our previous studies ...

Activation of pulmonary adventitial fibroblasts plays a key role in the pulmonary vascular remodeling in hypoxic pulmonary hypertension. Previous studies showed that miRNAs participated in the ...

Angiotensin-II production in the subfornical organ acting through angiotensin-II type-1 receptors is necessary for polydipsia, resulting from elevated renin–angiotensin system activity. Protein kinase ...

Background—Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been ...

Angiotensin II (Ang II) is the predominant effector peptide of the renin–angiotensin system. Ang II contributes to vascular remodeling in many cardiovascular diseases (eg, hypertension, ...

Figure 2. Mean arterial pressure (MAP) was measured with rats fed a 0.4% NaCl diet for 7 d the final 4 d of which rats were treated with rapamycin or vehicle before switching to 4.0% NaCl diet for 21 ...

Cell therapy with bone marrow–derived mononuclear cells (BMCs) can improve recovery of cardiac function after ischemia; however, the molecular mechanisms are not yet fully understood. MicroRNAs ...

This validated high-throughput assay provides clinical-grade functional evidence to aid the classification of current and future SCN5A–Brugada syndrome variants of uncertain significance.