One common, but lesser-understood symptom of HD is irritability. Irritability can be deeply distressing for the person with ...

Welcome to Brainland, the bustling, 24/7 theme park in your head. There’s Memory Maze, Logic Log Flume, and of course, the ...

New research suggests that Huntington’s disease could cause the brain to rewire, like a road detour. While connections between some brain cells are shut down, the traffic seems to get re-routed, ...

Welcome to HDBuzz! This special page is for people who are new to Huntington’s disease, or new to the world of HD research. Reading the articles linked here will help you pick up the basics of what ...

For Huntington’s disease (HD), a lot of attention goes to the genetic change that causes HD, but new research is shining a light on something else – our epigenome. The word literally means, “above” ...

Imagine the gene that causes Huntington’s disease (HD) as a vast river. At its source is the CAG repeat – a genetic letter code that dictates how the river will flow. As the river moves downstream, it ...

This week, we heard an update from Roche about their huntingtin-lowering therapy, tominersen, currently being tested in the GENERATION HD2 trial. An independent data monitoring committee (iDMC) that ...

What if a blood test could provide information about the status and course of HD? This is the premise of seeking HD biomarkers; they may someday help guide treatment decisions and predict how symptoms ...

Last month, we relayed positive news from uniQure’s trial testing AMT-130, a gene therapy delivered via brain surgery to lower huntingtin (HTT). Data released by uniQure in June suggested AMT-130 was ...

We often think of the adult brain like a completed jigsaw puzzle—once all the pieces are in place, that’s it. If a few pieces go missing, as happens in neurodegenerative diseases like Huntington’s ...