Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, has been implicated in the pathogenesis of AD. Objective: To investigate the use of a biologic TNF-alpha inhibitor, etanercept was ...

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008. Schematic of TNF inhibitors and their mode of action.

During his presentation, Dr. Glass spoke about the Company’s small-molecule TNF-alpha (TNF-α) inhibitor, isomyosamine, which has shown potential for regulating pro-inflammatory cytokines ...

Additionally, reductions in the inflammatory chemical called tumor necrosis factor alpha (TNF-α) correlated with cognitive improvements, suggesting that senolytics might enhance cognitive ...

This function may be exploited for microRNA-mediated ... (A+U)-rich elements in the 3′ untranslated region (UTR) of the TNF alpha mRNA. Now the researchers introduce a miRNA as the mediator ...