Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

More information: Jaakko Mattila et al, Stem cell mTOR signaling directs region-specific cell fate decisions during ...

TOKYO -- In a world first, a pipelike "miniature intestine" has been created using human iPS (induced pluripotent stem) cells ... to the same size as a mouse's small intestine.

These components of the small intestine would need to be generated ... Although cell-based therapy such as hematopoietic stem cell transplantation has been practiced for decades, the use of ...

In particular, discoveries related to the control of stem cell proliferation and how dysregulation of proliferation leads to oncogenesis have been foremost. For intestinal stem cells, the WNT ...

How does a stem cell know its position in a tissue, and how the positional information affects its properties? To address these fundamental biological question, we use fast spinning disc confocal ...

Figure caption, The properties and functions of stem cells in animals Some locations in the adult body, such as the lower layers of the skin and small intestine, still contain populations of stem ...