You have full access to this article via your institution. To demonstrate the power of PCR–mediated recombination and provide an example of the general utility of the method, we constructed ...

The authors generated mutant mice in which the RAG proteins could interact with and bind to DNA normally without initiating V(D)J recombination and assessed RAG protein binding, as well as the ...

The world market for recombinant proteins remains strong, with North America and Europe dominating research and development as a result of their strong biopharmaceutical industries. The Asia-Pacific ...

These include the ATM and NBS1 proteins that are part of the DSB sensing complex, and the BRCA2 protein that binds to the resected ssDNA (Yang et al., 2002) and catalyzes the formation of the ...

coli, expressed protein accumulates as insoluble inclusion bodies and several strategies can ... and baculovirus transfer plasmids and isolates recombinant baculoviruses that arise by homologous ...

"Because meiotic crossover recombination is essential to get the ... elegans, Bhalla's team discovered that a protein known as PCH-2 plays an important role in regulating crossover events.

Common to these genomic integrity pathways is eventual repair by homologous recombination, a process that has been a longstanding focus of ... In an eagerly awaited study, Memorial Sloan Kettering ...

Novel RBM39 molecular glue achieves complete tumor regression in mechanism-based Ewing sarcoma models; IND filing expected ...

Arvinas to present preclinical data for PROTAC BCL6 degrader & ARV-393 at 2025 AACR annual meeting in Chicago: New Haven, Connecticut Wednesday, April 23, 2025, 18:00 Hrs [IST] Ar ...

ARV-393 is Arvinas’ investigational PROteolysis TArgeting Chimera (PROTAC) degrader targeting the B-cell lymphoma 6 protein (BCL6), a transcriptional repressor and major driver of B-cell lymphomas.