The identification of new and safe antifungals with novel modes of action is now vital. Writing in Nature, Deng et al. report the discovery of a novel polyene antifungal, mandimycin, that exhibits ...

the armamentarium of antifungal agents for management of IFDs derived from just three major chemical classes: the azoles (including di- and triazoles), echinocandins and polyenes. Drugs from these ...

Discovering antifungals with novel mechanisms of action is essential in the fight against drug-resistant fungi, which pose a serious concern for public health. However, progress on new antifungals is ...

The drugs are categorized by their specific mechanism of action and can be broken down into four general groups: polyene antifungals, azole antifungals, antimetabolite antifungals, and echinocandins.

An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the ... such as ...