The nicotinic acetylcholine receptor (AChR) is assembled on the cell surface from multiple subunits produced in the endoplasmic reticulum (ER), but how these mechanisms are controlled has been unclear ...

Box 1 Nicotine receptor subunits. The nicotinic acetylcholine receptor (nAChR) gene family encodes ten α subunits (α1–10), four β subunits (β1–4), and single γ, δ, and ε subunits.

Additional studies in collaboration with Ibañez-Tallon showed that lynx-1 altered the function of nicotinic acetylcholine receptors. Acetylcholine is a neurotransmitter that helps to activate muscles ...