c-Kit signalling activates the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways and their relative contribution to the activities of oncogenic and ligand ...

Mitogen-activated protein kinase (MAPK) cascades have been shown to play a key role in transduction extracellular signals to cellular responses. In mammalian cells, three MAPK families have been ...

阿尔茨海默病（AD）临床治疗效果不佳。p38MAPK参与 AD 发病机制，针对 MAPK 的研究尝试探究其对记忆等的影响。相关 MAPK 抑制剂临床试验有积极成果，但存在问题。本文聚焦 MAPK 干预疗法治疗 AD 的临床研究，值得关注。 阿尔茨海默病现状 阿尔茨海默病（AD ...

水稻粒型和叶角是决定产量的关键农艺性状，但其调控机制尚不明晰。研究人员开展了 OsBSKs（BRASSINOSTEROID - SIGNALING KINASES）和 OsMAPKs（MITOGEN ACTIVATED PROTEIN KINASE）调控水稻粒型和叶角的研究，发现了其关键作用及调控机制，为水稻增产研究提供重要依据。 粒型和 ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

Factors impacting enrollment on NCI-COG Pediatric MATCH trial treatment protocols. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This abstract does not include a full text ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced that its management team is schedu ...

Shares of Pasithea Therapeutics Corp. (KTTA) soared as high as about 150% on Tuesday morning before paring back some of the gains after it announced positive data from its ongoing Phase 1 trial of PAS ...

The team demonstrated that tumor cells make new fat through the KRAS-MAPK pathway. "KRAS is the master regulator of pancreatic cancer, and new medicines are now in clinical trials to bring down ...

Molecular and clinical characteristics of POLE/POLD1 alterations among patients with colorectal cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Gastrointestinal Cancers Symposium. This ...