These strategies could turn what is now an impediment into a significant advantage for cancer therapy. Therefore, hypoxia has a key negative role in tumour prognosis both because it causes ...

As reported today in Nature Genetics, researchers have discovered molecular hallmarks of hypoxia in the first-ever pan-cancer analysis of low oxygen in human tumours, with a special focus on ...

To effectively battle cancer, scientists must study the battlefield. Now, in a recent study published in Nature ...

Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help ...

New Treatments for Advanced Hodgkin’s Disease: An Uphill Fight Beginning Close to the Top So, with the problem being a “bad outcome” in terms of local tumor control and survival for the patient, is ...

Hypoxia-activated prodrugs (HAPs) have the potential to activate specifically in hypoxic tumors and eliminate tumor cells, which has brought new opportunities for safe and effective anticancer ...

One key study found that lung cancer incidence decreases as elevation increases. For every 1,000 meters rise in altitude, ...

Pancreatic cancer is notoriously resistant to chemotherapy and radiotherapy due to an extremely complex tumour microenvironment (TME, the tissues surrounding a cancerous lesion) characterized by the ...

When tissues are starved of oxygen (hypoxia), cancer cells in the affected area send chemical signals to get the endothelial cells that line the blood vessels to form new vessels. A new study by ...