本综述深入探讨了缺氧（Hypoxia）、肿瘤干细胞特性（Cancer Cell Stemness）与药物耐受性（Drug Resistance）之间的复杂关系，揭示了其在肿瘤治疗中的关键作用。 肿瘤微环境中的缺氧是实体瘤的常见特征，与肿瘤的侵袭性、复发和治疗耐受性密切相关。缺氧能够诱导 ...

Antibiotics increase the gut oxygen levels and favor growth of harmful fungi. Chemically restoring intestinal gut hypoxia ...

de la Calle-Fabregat, C., et al. (2024) NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the ...

I n the complex landscape of cancer, tumors create their own microenvironment, often marked by low oxygen levels, a condition known as hypoxia. Hypoxia arises as tumors grow rapidly, outpacing ...

Resistant cancer cells exhibit traits like drug efflux, enhanced DNA repair, protein homeostasis, and an immunosuppressive ...

The team's findings were published in the paper "Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation," from Cancer Discovery.

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...