determined the structures of the related F-BAR domains from formin-binding protein-17 (FBP17 ... harness the membrane-deforming capabilities of actin filaments — the recruitment of FBP17 ...

Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family.

Purified formins in vitro produce long (>50 μm) actin filaments. However, most in vivo actin structures are composed of relatively short (<1 μm) filaments, highlighting the importance of regulating ...

and are rich in actin or protein filaments. A specific type of Formin protein can activate these filaments and cause them to assemble. Dr. Lin Kun Yang, who was a research fellow at Duke-NUS at ...