Here we show that CP and formin mDia1 can together bind to actin filament barbed ends in a ternary complex in which CP acts as an uncompetitive inhibitor of formin. The dynamics of formin and CP ...

Actin achieves this by assembling into filaments, one actin molecule at a time. The proteins of the formin family are pivotal partners in this process: positioned at the filament end, formins ...

The formin family of proteins have been implicated ... are specifically required for the assembly of bundles of parallel actin filaments known as cables.

In the speculative models suggested so far, formins interact through all their four binding domains with actin, while slow and fast-moving formin would adopt different shapes at the filament. “But ...

Research into how proteins act individually on actin is relatively well-characterized. A polymerase protein, such as formin, drives elongation of actin. Formin positions itself at the end of an ...

Finally, Shekhar’s team wanted to know how CAP affected the activity of other actin regulatory proteins such as formin, which helps polymerize the barbed end, and capping protein, which halts filament ...

However, most in vivo actin structures are composed of relatively short (<1 μm) filaments, highlighting the importance of regulating formin activity to produce cellular actin structures of a precise ...

The OSU study (“ACD toxin–produced actin oligomers poison formin-controlled actin polymerization”), which is published in Science, shows that one toxin linked to cholera and other diseases ...

They found that knocking down the Formin homology 2 domain containing ortholog (Fhos) gene in fruit fly neurons prevented F-actin accumulation in the brain. “When we reduced Fhos expression in ...

The arrangement of actin within cells is regulated by another type of protein called formin, which accelerates the assembly of a particular actin, filamentous actin (f-actin). “We decided to ...

and are rich in actin or protein filaments. A specific type of Formin protein can activate these filaments and cause them to assemble. Dr. Lin Kun Yang, who was a research fellow at Duke-NUS at ...

In the speculative models suggested so far, formins interact through all their four binding domains with actin, while slow and fast-moving formin would adopt different shapes at the filament.