By the late 1990s, scientists had managed to identify drugs that worked against mutant proteins that function in specific signaling pathways that cancer cells rely on—a step that ushered in a ...

The Cell Identity and Signaling (CIS) Research Program is comprised of faculty members at Purdue University in the broad range of research areas from basic science studies using non-mammalian model ...

"We found that the p53 tumor-suppressor signaling pathway is silenced in cells with DNMT3A mutations, which in turn increases the likelihood that these cells will accumulate additional cancer ...

Researchers suspected these gut microbial modifications could affect how bile acids function and interact with human signaling pathways ... cells to fight tumors. The investigators wondered whether ...