By the late 1990s, scientists had managed to identify drugs that worked against mutant proteins that function in specific signaling pathways that cancer cells rely on—a step that ushered in a ...

A new publication shines a spotlight on HER3, a long-overlooked member of the ErbB receptor family, revealing its critical role in cancer progression and resistance to therapy.

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional ...

Combining EPO inhibition with an immunotherapy that further activates these immune cells against the cancer led to complete ... blocking the EPO signaling pathway and anti-PD-1 pathway.

Researchers have shown that activation of the protein YAP, known to help cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, ...

A study on fasting and the ketogenic diet uncovers a newfound weakness in pancreatic tumors, making them more susceptible to ...

Researchers suspected these gut microbial modifications could affect how bile acids function and interact with human signaling pathways ... boosted the activity of T cells—the immune cells best ...