[1] During the last decades, the use of HEp-2 cells as substrates for IIF has allowed the identification of ANA patterns which are difficult or even impossible to appreciate on tissue sections ...

The MND ANA pattern is immunomorphologically characterized by the staining of 3–20 dots of variable size distributed throughout the cell nucleus, but sparing the nucleoli and the mitoses (Figure 2).

Across the globe, children with RF-negative polyarticular JIA exhibit differences in clinical features, disease activity, and treatment patterns.