To track the expression of a specific AAV genome in a pool, researchers add a unique pair of small barcodes consisting of a few nucleotides to the AAV sequence. Each viral genome also contains two ...

First, the researchers developed an AAV (AAV-Sia6e) that can deliver genome editing tools to a wide range of inner ear cells that form gap junctions. AAV is a useful vector for delivering genes ...

First, the researchers developed an AAV (AAV-Sia6e) that can deliver genome editing tools to a wide range of inner ear cells that form gap junctions. AAV is a useful vector for delivering genes ...

First, the researchers developed an AAV (AAV-Sia6e) that can deliver genome editing tools to a wide range of inner ear cells that form gap junctions. AAV is a useful vector for delivering genes ...

ddPCR technology then amplifies and detects the ligated oligo pairs, while an ITR-2 assay simultaneously detects the AAV genome. Software analyzes the signals from each capsid type to calculate ...

Scientists from Juntendo University and The University of Tokyo have created an adeno-associated virus (AAV)-based genome editing approach to treat genetic hearing loss caused by the GJB2 R75W ...

Maple syrup urine disease (MSUD) is a rare genetic inborn error of metabolism characterized by recurrent life-threatening neurologic crises and progressive brain ...

As such, AAV-mediated gene editing is highly efficient (up to 20 percent targeting efficiency ... In addition, mutations in cohesin are increasingly seen in cancer genome sequencing. These and other ...