Adding topotecan to carboplatin plus paclitaxel, the standard treatment for ovarian cancer, does not improve progression-free survival in patients and leads to greater toxicity, according to a new ...

NICE to publish final guidance on topotecan for the treatment of small-cell lung cancer and preliminary recommendations for bevacizumab for metastatic colorectal cancer NICE will be making two ...

4.1 The Appraisal Committee reviewed the data available on the clinical and cost effectiveness of topotecan, having considered evidence on the nature of recurrent and stage IVB cervical cancer and the ...

Sixty-one patients younger than 21 years with newly diagnosed metastatic RMS or undifferentiated sarcoma were assigned window therapy (weeks 0 to 6) with topotecan (0.75 mg/m 2 daily × 5 every 21 days ...

The newly-reported data at the 2014 ASCO meeting come from another group of 59 patients randomized 1:1 to receive either lurbinectedin or topotecan (Hycamtin®; GlaxoSmithKline). Lurbinectedin ...

Teva Pharmaceuticals has initiated a voluntary recall of 1 lot of Topotecan Injection 4mg/4mL (1mg/mL) due to the presence of particulate matter. Topotecan Injection, as a single agent ...

Etoposide is an injectable used for testicular and small cell lung cancer, and topotecan is used for ovarian, cervical and small cell lung cancer. Six solutions for etoposide are on back order ...

ORRs were 38% (95% CI, 20% to 56%) for the amrubicin arm and 13% (95% CI, 1% to 25%) for the topotecan arm. In sensitive relapse, ORRs were 53% for the amrubicin arm and 21% for the topotecan arm. In ...

The Appraisal Committee (appendix A) considered evidence submitted by the manufacturer of topotecan and a review of this submission by the Evidence Review Group (ERG; appendix B). 3.1 In the ...