来自台湾阳明大学，台湾大学的研究人员发表了题为“Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair”的文章，指出了癌细胞在DNA修复过程中需要胸苷激酶，来阻止dUTP的掺入，这说明了胸苷激酶对于癌细胞DNA修复的重要性，也表明了针对这种 ...

Since the 1940s, inhibitors of thymidylate biosynthesis have remained among the most effective chemotherapies used in the treatment of cancer The enzyme thymidylate synthase (TS) is a key ...

Notably, such a chemical mechanism is very different from that of classical thymidylate synthases, and along with structural differences, may help explain why classical thymidylate synthase ...

The authors indicated no potential conflicts of interest. Fig 1. Funnel plot of hazard ratios (HR) of overall survival in all advanced disease studies associated with a high level of thymidylate ...

Preclinical and clinical results in advanced and adjuvant colorectal cancers confirmed that the therapeutic efficacy of fluoropyrimidines, with thymidylate synthase (TS) as a primary target, can be ...