This Review discusses the role of telomeric proteins in cancer and ageing through modulating telomere length and protection, as well as regulating gene expression by binding to non-telomeric sites.

Here we show that a large fraction of exogenously induced persistent DDR markers is associated with telomeric DNA in cultured cells and mammalian tissues. In yeast, a chromosomal DNA double-strand ...

View Full Profile. Learn about our Editorial Policies. In normal mammalian cells, a small telomeric DNA segment is lost after each cell cycle, gradually eroding to a critical length. At this point, ...

Their paper is titled “Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA damaging agents.” Cancer cells with intact DNA repair mechanisms can avoid the ...

The extreme ends of every telomere are not blunt, as the 3’ single-stand overhang comprises 200 nucleotides and loops back with some of the double-stranded telomeric DNA to make a telomere loop ...

These findings indicate that it is the DNA damage response activation, rather than telomeric shortening per se, that is responsible for ACE2 upregulation. Understanding the mechanism of age ...

Telomere deprotection will be evaluated by monitoring the emergence of telomere dysfunctioninduced foci (TIFs, which mark telomeric DNA damage) 20 upon inhibitor treatment of cells, using ...

There is a need regarding cardiovascular disease and heart failure for a therapy that reverses the progression of ventricular dysfunction. Previous findings have shown that cardiomyocytes during ...

Here we show that the unique N-terminus of PfORC1 (PfORC1N1–238) is targeted to the nuclear periphery in vivo and this region binds to the telomeric DNA in vitro due to the presence of a leucine ...

Telomeres are DNA-protein complexes that cap the ends of chromosomes and promote genetic stability. Each time a cell divides, a portion of telomeric DNA dwindles away, and after many rounds of cell ...