Metformin, a biguanide, and various sulphonylureas are two classes of oral drugs that are widely used and have robust single-agent potency (∼1.5% HbA1c reductions). Metformin is a safe ...

Monotherapy for type two diabetes patients with most sulphonylureas has a higher risk of all-cause and cardiovascular death compared with metformin, say researchers. Compared to metformin, patients ...

Sulphonylureas are the class of antidiabetic drug for type 2 diabetes that tends to include those drugs which end in ‘ide’. The following drugs are all in the sulphonylureas class (branded names in ...

We performed extensive sensitivity analyses to test the robustness of results to variation in inputs and assumptions. Results: Sulphonylureas, when added to metformin, were associated with the most ...

They are taken up to three times a day prior to meals – up to 30 minutes before eating – in order to limit subsequent post-meal spikes in blood glucose levels The way they achieve this is by ...

More evidence is emerging that prescribing sulphonylureas to patients with diabetes increases their cardiovascular risk when compared to metformin. New research shows patients who were initiated with ...

May 15, 2011 (Honolulu, Hawaii) — The insulin-releasing properties of sulphonylureas may include antidepressant effects, according to a large retrospective study reported here Sunday at the ...

It is more common in people with type 1 diabetes, who have, on average, two episodes of mild hypoglycaemia per week; 10% have a severe episode of hypoglycaemia annually (Cryer et al, 2003) compared ...