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Nature Genetics:破解癌症免疫逃逸密码!PD-L1琥珀酰化改写黑色素瘤 ...
更颠覆认知的是,被称为"脂肪燃烧酶"的CPT1A竟藏着第二重身份——它能像分子剪刀般将PD-L1送入溶酶体销毁。当研究者给小鼠注射降脂药苯扎贝特(Bezafibrate)激活CPT1A时,肿瘤体积在21天内缩小82%,联合CTLA-4抗体后甚至实现完 ...
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