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The minor spliceosome: Researchers reveal new structural insights into an essential RNA-protein complex
In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells remove ...
Nature21d
Genetics opens new route to degrader discovery
It was subsequently found to drive degradation of subunits in a transcriptional repressor complex ‘LHC’, comprised of the histone demethylase LSD1, the histone deacetylase HDAC1 (or HDAC2 ...
Chromatography Online12d
An LC–HRMS Method for Separation and Identification of Hemoglobin Variant Subunits
Researchers from Stanford University’s School of Medicine and Stanford Health Care report the development of a liquid ...
STAG2 protein mutations and associated spatial alteration of DNA structure can contribute to development of leukemia
It helps to properly fold the DNA and thus regulate gene activity. Cohesin contains two very similar subunits, STAG1 or STAG2 ...
Nature2y
RNA Transcription by RNA Polymerase: Prokaryotes vs Eukaryotes
This polymerase contains four catalytic subunits and a single regulatory subunit known as sigma (s). Interestingly, several distinct sigma factors have been identified, and each of these oversees ...