Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase. Animal studies have demonstrated ...

Appendix 1. Author Relationships With Industry and Other Entitiese 717 Appendix 2. Reviewer Relationships With Industry and Other Entitiese 720 Since 1980, the American College of Cardiology (ACC) and ...

Appendix 1. Author Relationships with Industry and Other Entities (Relevant) e115 Appendix 2. Reviewer Relationships with Industry and Other Entities (Comprehensive) e117 When developing ...

Preeclampsia (PE) is a common human-specific pregnancy disorder defined by hypertension and proteinuria during gestation and responsible for maternal and fetal morbimortality. STOX1, encoding a ...

The sympathetic nervous system plays a fundamental role in the regulation of myocardial function. During chronic pressure overload, overactivation of the sympathetic nervous system induces the release ...

Studies used adult SS rats (Medical College of Wisconsin) maintained ad libitum on water and a standard pellet diet containing 0.4% NaCl since weaning. All studies were conducted in accordance with ...

The function of Nox4, a source of vascular H 2 O 2, is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction. We determined the function of Nox4 in situations of ...

Aberrant regulation of the proliferation, survival, and migration of endothelial cells (ECs) is closely related to the abnormal angiogenesis that occurs in hypoxia-induced pathological situations, ...

The present document is a comprehensive guideline statement on the management of patients with acute ischemic stroke that supercedes the prior statement and interim updates. 1–3 These guidelines have ...

To test the effects of long‐term RD on SHRcp rats, they were followed for 19 weeks after RD. SHRcp rats (n=22) were divided into 2 groups: one received bilateral RD (RD group, n=11), and the other ...

Significant mitral regurgitation (MR) is an increasingly common disorder affecting nearly 10% of the US population aged >75 years and is associated with increased morbidity and mortality in the ...

Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A subset of patients have a hereditary form of ...