In contrast, off-target effects for siRNA are much more difficult to classify, as short stretches of sequence homology may exist among RNA molecules encoding structurally distinct classes of ...

siRNA能抑制特定致癌基因表达，展现出较好的抗肿瘤潜力。然而其临床应用面临多重障碍，如负电荷亲水性阻碍细胞摄取，溶酶体逃逸能力不足导致 ...

(Table 1) The efficiency and specificity of RNAi depend on the position and sequence of the siRNA used. So how do you pick out the right 21-nucleotide sequence to knock down your favorite gene?

Given the growing antibiotic resistance crisis, novel ways to target bacterial infections are becoming increasingly important. One potential strategy is to manipulate bacterial genes at the ...

In SNALPs, the backbone-modified siRNA is encapsulated within a closed shell of a cationic-zwitterionic lipid bilayer, furnished with an outer PEG shield (Figure 2A). The lipid bilayer contains a ...

Nanomedicine. 2014;9(1):105-120. Overall, HDL-based siRNA delivery possesses many attractive features, including ultra-small size, favorable surface properties (no PEGylation is required for ...