Here we developed an analytical platform based on a combination of quantitative light and electron microscopy (EM) to dissect the mechanisms of LNP-mediated siRNA delivery with high resolution.

近日，上海交通大学张川教授团队与复旦大学附属眼耳鼻喉科医院洪佳旭主任医师团队合作，在 Advanced Materials 期刊发表了论文。 研究结果为 ...

The overall result from all the discoveries is a mechanism for siRNA administration that starts with the bonding of siRNAs to particular fatty acids. This combination is linked to lipophilic ...

文章报道了新型肝脏血管紧张素原靶向siRNA候选药物的临床前开发过程——经生物信息学筛选、化学修饰优化及结合肝脏靶向配体，成功开发出了数 ...

The overall result from all the discoveries is a mechanism for siRNA administration that starts with the bonding of siRNAs to particular fatty acids. This combination is linked to lipophilic ...

which successively remove siRNA duplexes from the dsRNA termini (Weinberg et al. 2011). Weinberg, D., Nakanishi, K., Patel, D. J. & Bartel, D. P. (2011). The inside-out mechanism of Dicers from ...

As multiple companies vie to expand on Alnylam’s success in commercializing RNAi therapeutics, the pioneering company has set ...

The knowledge gained by understanding the mechanism of action of naturally occurring siRNAs in mammalian cells has opened new possibilities for synthetically designed siRNA as therapeutics.

The second stage of RNAi mechanism involves guide strand (duplex of siRNA and miRNA) incorporation. Guide strands are single strand duplexes of the miRNA and siRNA, and are integrated into ...

It's estimated that this cancer-killing siRNA mechanism arose over 800 million years ago, and now humans have discovered it, hopefully we can improve on it to develop effective cancer treatments.

today announced the presentation of preclinical data that demonstrate a mechanism of uptake and trafficking of ligand-siRNA conjugates using megalin receptors to achieve targeted gene knockdown in ...