The proteasome is an abundant, catalytic complex that is found in both the nucleus and cytoplasm of eukaryotic cells. The function of the proteasome is to degrade or process intracellular proteins ...

人体细胞内默默运转的"蛋白质碎纸机"——蛋白酶体（proteasome），竟是一个隐藏的抗生素制造工厂！ 在我们与病原体持续数百万年的军备竞赛中 ...

近日，武汉大学生命科学学院刘凯课题组与中国科学院生物与化学交叉研究中心张一小课题组合作在Science Advances杂志发表题为“ Molecular basis for the stepwise and faithful maturation of the 20S proteasome ”的研究论文，揭示了20S蛋白酶体组装成熟的分子机制，表明它是一个 ...

科学家们早就知道，细胞的“蛋白破坏机器”---蛋白酶体（proteasome）---在大脑内的蛋白清除中发挥着关键作用。然而，一项新的研究表明其作为蛋白 ...

But rather than the scavengers and microbial decomposers at work in macroscale habitats, much of the protein recycling work within the cell falls to a barrel-shaped protein complex known as the ...

For more than a decade, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.

Dr. Park's laboratory studies the biogenesis of a molecular machine known as the proteasome, a major protease in eukaryotes. Her studies have changed the traditional view of the spontaneous formation ...

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis is essential ...

Success as An Anti-Cancer Agent Has Fueled Efforts to Discover Proteasome Inhibitors That Raise Proteins Levels with Beneficial Effects The ubiquitin proteasome system (UPS) provides a mechanism ...

Much like humans generate mountains of garbage, our cells are constantly discarding proteins that are damaged or no longer needed. The cellular waste disposal system called the proteasome is best ...

Evžen Bouřa has succeeded in preparing a key enzyme complex – the proteasome. This has made it possible to gain knowledge that is indispensable for the development of new effective medicines.