为解决模块化聚酮合酶（modular polyketide synthases）装配线上非经典催化反应难以引入的问题，研究人员开展了相关研究。结果是在装配线聚酮合酶上成功插入硫酯还原酶（thioester reductase）结构域，实现非天然二醇的生物合成。该研究拓展了其催化功能，助力设计 ...

这两项研究借助于自然酶演化规律，发展了装配线式聚酮合酶的理性重编技术，构建了一座绿色化学工厂，为稳定获取多样化 ...

近日，上海交通大学生命科学技术学院、微生物代谢国家重点实验室邓子新团队在国际著名期刊德国应用化学《Angewandte Chemie》（IF：15.336）上发表题为“Unexpected Role of a Short-chain Dehydrogenase/Reductase Family Protein in Type II Polyketide ...

“We chose this specific polyketide because it is one of the hardest to work with and manipulate. Now we’ve devised a way to make it more quickly in the lab, this should make it easier to apply the ...

Enzymology of Polyketide Biosynthesis Many biologically active compounds are synthesised in nature via the polyketide pathway. The core of all polyketide structures is similar, and is assembled by a ...

Enzymes are substances that cause chemical reactions. Certain types of enzymes, such as polyketide synthases and nonribosomal peptide synthetases, have the ability to shuffle their parts ...

By changing this mold, chemists can control the size and shape of the polyketide, resulting in the formation of new drugs. “Almost every polyketide has rings in its chemical structure ...

By changing this mold, chemists can control the size and shape of the polyketide, resulting in the formation of new drugs. “Almost every polyketide has rings in its chemical structure ...

The research team is filing a patent for this process and have identified the amoeba Dictyostelium discoideum as a suitable chassis organism for polyketide production. To evaluate D. discoideum’s ...