近日来自上海交通大学生命学院的研究人员在DNA骨架硫修饰科学领域又取得新进展，揭示了DNA抗氧化损伤的新机制。相关论文“Phosphorothioate DNA as an antioxidant in bacteria”发表在公布在国际知名分子生物学刊物《Nucleic Acids Research》上。 生物通报道 近日来自上海 ...

β-S-ARCA(D1)-capped RNA has a longer physical half-life in immature DCs Our findings suggested that the superior protein yield from RNA species equipped with phosphorothioate cap analogs in human ...

To provide a potential approach, the research groups of Weihong Tan and Xue-Qiang Wang at the Hangzhou Institute of Medicine used phosphorothioate backbone modification to enhance the recognition ...

Miravirsen is a locked nucleic acid–modified DNA phosphorothioate antisense oligonucleotide that sequesters mature miR-122 in a highly stable heteroduplex, thereby inhibiting its function.

However, the molecular mechanisms of plant fertilization remain largely unknown. We report a transient inhibition of gene function using phosphorothioate antisense oligodeoxynucleotides (AS-ODNs) ...

To provide a potential approach, the research groups of Weihong Tan and Xue-Qiang Wang at the Hangzhou Institute of Medicine used phosphorothioate backbone modification to enhance the recognition ...