The discovery of phosphatidylinositol 3-kinase (PI3K) changed the way we view and understand growth-factor signaling. From early on, it became clear that PI3K plays an important role in many ...

Phosphatidylinositol-3-OH kinase (PI(3)K) and the nutrient sensor mTOR are evolutionarily conserved regulators of cell metabolism. Here we show that PI(3)K and mTOR determined the repertoire of ...

Phosphoinositide signaling pathways have been implicated in the metabolic alterations associated with various human diseases, including breast cancer. The phosphatidylinositol-5-phosphate 4-kinase ...

Color coding is used to show the association patterns of best response status in all patients with evaluable biomarker samples and response data, with corresponding tumor baseline gene expression ...

Pain Management in Cancer Center Inpatients: A Cluster Randomized Trial to Evaluate a Systematic Integrated Approach—The Edinburgh Pain Assessment and Management Tool ...

PIP2 is an important phosphoinositide that is present in around 1% of the plasma membrane. It is also involved in signal transduction of intracellular and extracellular components. There are two ...