Henry and Housewright 1 described a manometric method for the assay of penicillinase which was based on the formation of penicilloic acid from penicillin in the presence of this enzyme.

Fleming, P. C., Goldner, M., and Glass, D. G., Lancet, i, 1399 (1963). Barber, M., and Waterworth, P. M., J. Clin. Path. (in the press). Henry, R. J., and Housewright ...

Penicillinase is an enzyme that acts on the β-lactam ring of penicillin to convert penicillin into penicillic acid, which has no antibacterial activity. A variety of penicillin-resistant bacteria can ...

Penicillinase, an enzyme that hydrolyzes and inactivates penicillin, is formed by various bacteria (staphylococci, Escherichia coli and Bacillus cereus) and has previously only been used in ...

Should the patient be treated with penicillin G (or some other penicillinase-susceptible penicillin) or with one of the penicillinase-resistant, semisynthetic penicillins, such as methicillin or ...

Most of the resistant strains were able to synthesise an enzyme, called penicillinase or β-lactamase, which deactivated the antibiotic through cleavage of the β-lactam ring. Penicillinase-stable ...

They can be divided into natural penicillins, penicillinase-resistant penicillins, aminopenicillins, carboxypenicillins and extended-spectrum penicillins. Penicillin G is natural penicillin ...

In most countries, S. aureus strains have developed a resistance to penicillin due to production of an enzyme by the bacteria called penicillinase. The first line therapy is penicillinase ...