Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancer ...

Their approach, described in Nature Chemical Biology on September 18, 2024, and dubbed “paralog hopping,” could uncover new binding sites for drugs and inform drug development more broadly ...

As a rotation project in the lab of Dr. Alice Berger, part of the Human Biology Division, Parrish started a CRISPR-Cas9 based approach to identify synthetic lethal paralog genes - or gene pairs that ...

A drug candidate (pink) found to bind to the pocket between the cancer-related protein CCNE1 (green) and its partner CDK2 (blue) using the new paralog-hopping approach. LA JOLLA, CA—Some ...

To design a drug that blocks a cancer-related protein, scientists took a hint from the protein's paralog, or 'twin.' Using innovative chemical biology methods, the scientists pinpointed a ...