The tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic phenotype is a result of interactions between prostate cancer cells and osteoblasts. Prostate cancer ...

Communication between osteoblasts and endothelial cells (ECs) is essential for bone turnover, but the molecular mechanisms of such communication are not well defined. Here we identify Cxcl9 as an ...

Osteoblasts are the cells required for bone synthesis and mineralization, both during the initial formation of bone and during bone remodelling. These cells are present on the bone surface in the ...

Their antiresorptive effects can be explained by inhibition of osteoclastic resorption, promoting osteoclast apoptosis. However, recent evidence also points to a direct action of bisphosphonates on ...

Researchers show that intercellular communication via extracellular vesicles from bone-making osteoblasts is a key factor for this switch through a microRNA-mediated mechanism. Bone remodeling ...

Adult bones are maintained by a balance of bone-forming osteoblasts and bone-resorbing osteoclasts. Although Wnt signaling affects this balance in mice and humans, the Wnt receptors involved ...

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts.

In the study, the researchers conducted biofunctionalization experiments with murine calvariae pre-osteoblasts (MC3T3-E1) to assess the osteogenic response on modified 3-D surfaces for BTE.

Bone is constantly formed, reformed, and remodeled throughout life, and up to 10% of human bone is replaced annually through a complex interplay between two cell types—osteoblasts, which form ...

It contains osteoblast cells. Osteoblasts are bone-forming cells. They’re very important during the fetal and childhood phases of life when bone tissue is still developing. As a result ...

Two specialized types of cells are responsible for the synchronized process of bone remodeling: Osteoblasts (bone-forming cells) and osteoclasts. Osteoclasts are large multinucleated cells with a ...

9 Not only is the balance of osteoblasts and osteoclasts altered, but the microenvironment of the osteocyte is also remodeled, leading to the increased apoptosis of osteocytes. Testosterone plays ...