Communication between osteoblasts and endothelial cells (ECs) is essential for bone turnover, but the molecular mechanisms of such communication are not well defined. Here we identify Cxcl9 as an ...

The tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic phenotype is a result of interactions between prostate cancer cells and osteoblasts. Prostate cancer ...

Osteoblasts are the cells required for bone synthesis and mineralization, both during the initial formation of bone and during bone remodelling. These cells are present on the bone surface in the ...

Researchers show that intercellular communication via extracellular vesicles from bone-making osteoblasts is a key factor for this switch through a microRNA-mediated mechanism. Bone remodeling ...

Their antiresorptive effects can be explained by inhibition of osteoclastic resorption, promoting osteoclast apoptosis. However, recent evidence also points to a direct action of bisphosphonates on ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone ...

In the study, the researchers conducted biofunctionalization experiments with murine calvariae pre-osteoblasts (MC3T3-E1) to assess the osteogenic response on modified 3-D surfaces for BTE.

Osteoporosis is the primary cause of bone fractures in the elderly, reflecting an imbalance between osteoclasts, bone-degrading cells, and osteoblasts, bone-building cells. Teriparatide is the ...

Bone is constantly formed, reformed, and remodeled throughout life, and up to 10% of human bone is replaced annually through a complex interplay between two cell types—osteoblasts, which form ...

Two specialized types of cells are responsible for the synchronized process of bone remodeling: Osteoblasts (bone-forming cells) and osteoclasts. Osteoclasts are large multinucleated cells with a ...

This molecule targets osteoblasts, the cells responsible for building and strengthening our skeletal framework, potentially offering a new lease on life for those grappling with fragile bones.

9 Not only is the balance of osteoblasts and osteoclasts altered, but the microenvironment of the osteocyte is also remodeled, leading to the increased apoptosis of osteocytes. Testosterone plays ...