My scientific interests center on nucleases, a functionally diverse class of enzymes that catalyze the cleavage of phosphodiester bonds to support a wide breadth of pathways, including DNA replication ...

Even when CRISPR nucleases are directly delivered into cells, their large protein sizes present limitations. For example, the commonly used Cas9 is about 1,400 amino acid residues long. “It's like a ...

Danielle is a Senior Editor at The Scientist. She has a background in neuroscience. Her science communication experience spans journalism, scientific publishing, and science education and outreach.

For each of two nucleases—Cas9 from Streptococcus pyogenes and Cas12 from Staphylococcus aureus—they identified three short sequences, about eight amino acids long, that evoked an immune response.