Despite the presence of a germline mutation in a MMR gene being a strong predictor of disease, there is considerable variation in the phenotypic expression in HNPCC patients, in particular the age ...

In this review we will focus on the two major forms of hereditary colorectal cancer, familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. The most important step leading ...

PURPOSE: Germline mutations in mismatch repair genes predispose to hereditary nonpolyposis colorectal cancer (HNPCC). To address effective screening programs, the true incidence of the disease must be ...

Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal cancer), conferring a strong ...

They include hereditary polyposis syndrome and hereditary nonpolyposis colorectal cancer. Hereditary polyposis syndrome increases the likelihood a person will develop polyps in their digestive tract.