Despite the presence of a germline mutation in a MMR gene being a strong predictor of disease, there is considerable variation in the phenotypic expression in HNPCC patients, in particular the age ...

In this review we will focus on the two major forms of hereditary colorectal cancer, familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. The most important step leading ...

Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal cancer), conferring a strong ...

Tumor-Specific Expression of Vascular Endothelial Growth Factor Receptor 2 but Not Vascular Endothelial Growth Factor or Human Epidermal Growth Factor Receptor 2 Is Associated With Impaired Response ...

A total of 155 persons completed study measures before HNPCC genetic testing, and at 2 weeks and 6 and 12 months after disclosure of test results. Mean scores on all outcome measures remained stable ...

They include hereditary polyposis syndrome and hereditary nonpolyposis colorectal cancer. Hereditary polyposis syndrome increases the likelihood a person will develop polyps in their digestive tract.