They form on the protective cover around your nerves. That’s called the sheath. Most plexiform neurofibromas (PNs) are benign, or non-cancerous. Some -- about 8% to 15% -- do turn into cancer.

ERIN DUNBAR: Plural neurofibromas are the signature abnormal tumor growth found in neurofibromatosis type 1, which is a heritable or familial or genetic condition, and plexiform neurofibromas are ...

Panelists discuss how MEK inhibitors, such as trametinib and selumetinib, are emerging as first-line treatments for symptomatic NF1-associated plexiform neurofibromas, especially in progressive or ...

Pasithea Therapeutics has announced the start of a Phase I/Ib open-label trial of macrocyclic mitogen-activated protein kinase (MEK) inhibitor, PAS-004, for treating adults with neurofibromatosis type ...

If approved, mirdametinib is expected to be the first and only therapy in the European Union with marketing authorization for ...

EMA committee recommends marketing approval for SpringWorks’ mirdametinib to treat adult & paediatric patients with NF1-PN: Stamford, Connecticut Tuesday, May 27, 2025, 12:00 Hr ...

Neurofibromatosis 1-associated plexiform neurofibromas (NF1-PN) are benign tumors that develop along peripheral nerves throughout the body. They are typically present at birth or develop in early ...

Exploratory objectives include assessing the effects of PAS-004 on cutaneous neurofibromas. The first active clinical trial site is the Royal North Shore Hospital in Sydney, Australia, which is ...

Snagging its second U.S. FDA approval since being spun out of Pfizer Inc. in 2017, Springworks Therapeutics Inc. is aiming to position Gomekli (mirdametinib), cleared for neurofibromatosis type ...

The FDA approved Gomekli for patients aged 2 years and older diagnosed with neurofibromatosis type 1 and symptomatic plexiform neurofibromas not amenable to complete resection. Image: Adobe Stock ...

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