Medpage Today on MSN6mon
Mania and Menopause; ADHD Drugs Still Scarce; Era of Muscarinic Agonists?
(JAMA Network Open) As an FDA decision nears on the muscarinic agonist xanomeline-trospium for schizophrenia -- which could ...
pharmaphorum3y
Cerevel soars on first data for muscarinic schizophrenia drug
The drug – a selective muscarinic M4 receptor positive allosteric modulator (PAM) – is designed to have limited effect on dopamine neurotransmission, a mechanism thought to contribute to ...
Nature5y
Tuning muscarinic receptor signalling
The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...
pharmaphorum1y
FDA kicks off review of Karuna’s schizophrenia drug KarXT
The US regulator has set an action date of 26th September next year for a decision on KarXT, which combines muscarinic agonist xanomeline tartrate and muscarinic antagonist trospium chloride ...