Nature10 年
ReCoGnizing methylated DNA
Surprisingly, the methyl groups of the symmetrically methylated CpG sequence are each recognized in a distinct manner. Base specificity results from multiple interactions. The guanine residues ...
Nature1 年
The Role of Methylation in Gene Expression
On the other hand, invertebrate animals generally have a "mosaic" pattern of methylation, where regions of heavily methylated DNA are interspersed with nonmethylated regions. The global pattern of ...
The Scientist2 年
Brush Up: What Is Bisulfite Sequencing and How Do Researchers Use It to Study DNA Methylation?
The gold standard technology that scientists use to detect DNA methylation is bisulfite genomic sequencing. It is a qualitative, quantitative, and efficient approach to identify methylated cytosine at ...
EurekAlert!22 天
DNA methylation as a biomarker for early diagnosis of lung cancer
The analysis identified 276 differentially methylated markers specific to lung cancer. Of the 276 predicted markers, six exhibited significantly different methylation statuses between lung cancer ...
来自MSN21 天
Early lung cancer diagnosis improved with ctDNA methylation biomarkers
The analysis identified 276 differentially methylated markers specific to lung cancer. Of the 276 predicted markers, six exhibited significantly different methylation statuses between lung cancer ...