Immunofluorescence showed staining of granular deposits for IgG and C3 along the glomerular basement membrane and in the mesangium. Other stains (C1q, IgA, IgM, fibrinogen, and albumin ...

However, the accepted explanation does not explain a unique hallmark of the disease: during the initial stages of IgAN, IgA deposition is seen in the mesangium, an area composed of mesangial cells ...

Panelists discuss how immunoglobulin A (IgA) nephropathy represents a complex glomerular disease characterized by IgA deposition in the mesangium, with a wide spectrum of clinical presentations ...