Known as macrocyclic peptides, these drugs are purported to create the Goldilocks effect—they have the size and shape to provide the advantages of both small- and large-molecule drugs without ...

2023年2月2日，该研究工作以Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P？Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance为题发表于Journal of Medicinal ...

Vancomycin 265/309 (85.8%) 76/265 (25.3%) 198/309 (64.1%) † Clinical cure is resolution of diarrhea following the recommended dose of drug (fidaxomicin: 200 mg twice a day; vancomycin: 125 mg ...

Phase 1 study of zavondemstat (TACH101), a first-in-class KDM4 inhibitor, in patients with advanced solid tumors: Results on safety, pharmacokinetics, and anti-tumor activity. Pertuzumab plus ...

Xiaoling Song and Ph.D. student, Yifan Wu (Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University), on the application of macrocyclic molecules in cancer treatment has ...

"Macrocyclic peptides have been challenging to translate into the clinic. But we're changing that. Our innovative ML tools and screening technologies drive our ability to rapidly optimize drug ...

At this week’s American Chemical Society Spring meeting, Galderma SA reported the discovery of novel, oral and selective macrocyclic inhibitors of protein kinase C θ (PKCθ) for the potential treatment ...

Xiaoling Song and a Ph.D. student, Yifan Wu (Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University) to summarize the application of macrocyclic molecules in cancer treatment.

Roche scientists identified the molecule, a macrocyclic peptide dubbed zosurabalpin, after a screen of 45,000 macrocyclic peptides found a few that killed A. baumannii and other double-membraned ...

Months after hailing macrocyclic peptides as the “next wave of drug discovery,” Merck & Co. has pushed further into the space by penning a $220 million biobucks deal with Unnatural Products.